40 days in Mexico & South America Itinerary

Created using Inspirock trip planner
Make it your trip
Fly
1
Guanajuato, Mexico
— 5 nights
Fly
2
Merida, Mexico
— 3 nights
Drive
3
Valladolid, Mexico
— 4 nights
Drive
4
Cancun, Mexico
— 6 nights
Fly to Capitán FAP Renán Elías Olivera International Airport, Drive to Ica
5
Ica, Peru
— 3 nights
Bus to Lima, Fly to Cusco
6
Cusco, Peru
— 5 nights
Drive
7
Machu Picchu, Peru
— 3 nights
Fly
8
Uyuni, Bolivia
— 5 nights
Fly to Foz do Iguacu, Bus to Iguazu National Park
9
Iguazu National Park, Argentina
— 3 nights
Fly to Comodoro Rivadavia, Bus to Perito Moreno
10
Perito Moreno, Argentina
— 1 night
+2
Bus to Balmaceda, Foot to Balmaceda, Fly to New York City

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Guanajuato, Mexico — 5 nights

Recognized as a World Heritage Site, Guanajuato spills over hilly terrain in central Mexico, luring visitors with its pleasant tree-shaded plazas and friendly sidewalk cafes.
Get out of town with these interesting Guanajuato side-trips: San Miguel de Allende (El Jardin, Museo Histórico Casa de Allende, &more). There's much more to do: admire the masterpieces at Museo Iconografico del Quijote, take in the exciting artwork at Artlalli, pause for some photo ops at Plaza Del Quijote, and see the interesting displays at Museo del Pueblo de Guanajuato.

To find maps, traveler tips, where to stay, and other tourist information, you can read our Guanajuato trip planner.

New York City, USA to Guanajuato is an approximately 10.5-hour flight. You can also drive; or do a combination of bus and taxi. The time zone difference moving from Eastern Standard Time to Central Standard Time is minus 1 hour. While traveling from New York City, expect warmer days and a bit warmer nights in Guanajuato, ranging from highs of 81°F to lows of 49°F. Cap off your sightseeing on the 11th (Sat) early enough to catch the flight to Merida.
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Parks · Museums · Outdoors · Tours
Side Trip
Find places to stay Mar 6 — 11:

Merida, Mexico — 3 nights

Yucatan's busy capital, Merida remains a mid-sized urban center offering an impressive list of cultural activities, eclectic nightlife, and a chance to see tropical examples of French and Italian architecture.
You'll find plenty of places to visit near Merida: Yucatan Snook (in Chuburna), Cenote Santa Rosa (in Homun) and Zona Arqueologica Uxmal (in Uxmal). There's lots more to do: delve into the distant past at Mayapan Archaeological Zone, make a trip to Ruta Puuc, look for gifts at Taller Maya, and tour the pleasant surroundings at Reserva de la Biosfera Ria Celestun.

To find more things to do, photos, maps, and more tourist information, read Merida vacation maker site.

Traveling by flight from Guanajuato to Merida takes 4.5 hours. Alternatively, you can drive; or do a combination of taxi and bus. The time zone difference when traveling from Guanajuato to Merida is 1 hour. Prepare for a bit warmer weather when traveling from Guanajuato in March: high temperatures in Merida hover around 93°F and lows are around 69°F. Finish your sightseeing early on the 14th (Tue) to allow enough time to drive to Valladolid.
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Wildlife · Historic Sites · Parks · Outdoors
Side Trips
Find places to stay Mar 11 — 14:

Valladolid, Mexico — 4 nights

Sultana of the East

One of the gateways to the ruins of Chichen Itza, Valladolid boasts plenty of historic charm and offers a range of tourist-oriented services that ensure pleasant holidays in this area.
Change things up with these side-trips from Valladolid: Cenote Yokdzonot (in Yokdzonot), Chichen Itza (Chichen Itza & Cenote Ik kil) and Ek Balam (in Ek Balam Village). Next up on the itinerary: stroll through Xkopek Parque Apicola, admire the masterpieces at Museo de Ropa Etnica de Mexico, Head underground at Cenote Xkeken, and don't miss a visit to Convent of San Bernardino of Siena.

Quickly create a custom-made itinerary for Valladolid using our trip planner.

Drive from Merida to Valladolid in 2 hours. Alternatively, you can take a shuttle; or take a bus. Traveling from Merida in March, plan for a bit warmer nights in Valladolid, with lows around 77°F. Finish up your sightseeing early on the 18th (Sat) so you can go by car to Cancun.
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Parks · Nature · Historic Sites · Museums
Side Trips
Find places to stay Mar 14 — 18:

Cancun, Mexico — 6 nights

Few destinations in Mexico dazzle visitors quite like Cancun, a modern resort town filled with glitzy hotels sitting on picturesque and well-developed Caribbean beaches.
Explore Cancun's surroundings by going to Playa del Carmen (Scuba & Snorkeling, Zipline, &more). Next up on the itinerary: buy something for everyone on your list at La Isla Shopping Village, explore the ancient world of Zona Arqueologica El Rey, indulge in some personalized pampering at some of the best spas, and enjoy the sand and surf at Playa Tortugas.

For photos, other places to visit, reviews, and more tourist information, read our Cancun trip planner.

You can drive from Valladolid to Cancun in 2 hours. Other options are to take a shuttle; or take a bus. Plan for a bit cooler temperatures traveling from Valladolid in March, with highs in Cancun at 82°F and lows at 70°F. Wrap up your sightseeing on the 24th (Fri) to allow time to travel to Ica.
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Outdoors · Tours · Wildlife · Parks
Side Trip
Find places to stay Mar 18 — 24:

Ica, Peru — 3 nights

Located on the Ica River in the desert areas of Peru's southern coast, the city of Ica stands as something of an oasis in the dry, barren landscape.
Get out of town with these interesting Ica side-trips: Paracas (Like Xplorer Peru & The Chandelier). There's lots more to do: learn about winemaking at Tacama, examine the collection at Regional Museum of Ica, get outside with Outdoor Activities, and savor the flavors at Food & Drink.

To see reviews, traveler tips, photos, and more tourist information, refer to the Ica travel route planner.

Use the Route module to find suitable travel options from Cancun to Ica. Expect a daytime high around 82°F in March, and nighttime lows around 67°F. Wrap up your sightseeing on the 27th (Mon) to allow time to travel to Cusco.
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Tours · Wineries · Outdoors · Wildlife
Side Trip
Find places to stay Mar 24 — 27:

Cusco, Peru — 5 nights

Imperial City

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Explore the numerous day-trip ideas around Cusco: Cerveceria Willkamayu (in Urubamba) and Yucay Museo de Cultura Viva (in Yucay). On the 28th (Tue), spend a fun day on foot with Walking tours. Next up on the itinerary: explore the ancient world of Sacsayhuaman, take a stroll through San Blas, pause for some serene contemplation at Cusco Cathedral, and get engrossed in the history at Museo Inka.

Planning Cusco trip won't be overwhelming when you use Inspirock's itinerary maker.

Do a combination of bus and flight from Ica to Cusco in 8.5 hours. Alternatively, you can drive; or take a bus. When traveling from Ica in March, plan for a bit cooler days and much colder nights in Cusco: temperatures range from 68°F by day to 46°F at night. Wrap up your sightseeing on the 1st (Sat) early enough to drive to Machu Picchu.
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Historic Sites · Tours · Museums · Neighborhoods
Side Trips
Find places to stay Mar 27 — Apr 1:

Machu Picchu, Peru — 3 nights

A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Machu Picchu is known for historic sites, nature, and sightseeing. Your trip includes some of its best attractions: steep yourself in history at Santuario Historico de Machu Picchu, explore the ancient world of Winay Wayna, don't miss a visit to Intipuncu, and stroll through Mandor.

For more things to do, reviews, maps, and tourist information, read Machu Picchu day trip planning tool.

You can drive from Cusco to Machu Picchu in 4.5 hours. Other options are to do a combination of bus and train; or take a train. Finish your sightseeing early on the 4th (Tue) to allow enough time to fly to Uyuni.
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Historic Sites · Wildlife · Parks · Spas
Find places to stay Apr 1 — 4:

Uyuni, Bolivia — 5 nights

Emptiness surrounds the desert outpost of Uyuni, the gateway to the world's largest salt flats.
Go for a jaunt from Uyuni to Potosi to see Pueblo Pulacayo about 40 minutes away. The adventure continues: explore the striking landscape at Salar de Uyuni, make a trip to Plaza Arce, see the interesting displays at Museo de la Llama y la Sal, and get the lay of the land with Walking tours.

For where to stay, other places to visit, more things to do, and other tourist information, read Uyuni visit planner.

You can fly from Machu Picchu to Uyuni in 6.5 hours. Alternatively, you can drive; or do a combination of train and bus. The time zone difference when traveling from Machu Picchu to Uyuni is 1 hour. In April, daytime highs in Uyuni are 48°F, while nighttime lows are 46°F. Wrap up your sightseeing on the 9th (Sun) early enough to travel to Iguazu National Park.
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Tours · Parks · Nature · Historic Sites
Side Trips
Find places to stay Apr 4 — 9:

Iguazu National Park, Argentina — 3 nights

Iguazu National Park contains 672 sq km (259 sq mi) of fertile subtropical forests, but its main attraction is the majestic Iguazu Falls.
Kick off your visit on the 10th (Mon): admire the sheer force of Iguazu Falls. Get ready for a full day of sightseeing on the next day: head off the coast to Isla San Martin, then admire the sheer force of Salto Bernabe Mendez, and then take in the dramatic scenery at Salto San Martin.

To see ratings, maps, where to stay, and more tourist information, use the Iguazu National Park trip builder.

Traveling by combination of flight and bus from Uyuni to Iguazu National Park takes 16.5 hours. Alternatively, you can drive; or take a bus. You'll lose 1 hour traveling from Uyuni to Iguazu National Park due to the time zone difference. When traveling from Uyuni in April, plan for much hotter days in Iguazu National Park, with highs around 81°F, while nights are a bit warmer with lows around 62°F. Finish your sightseeing early on the 12th (Wed) to allow enough time to travel to Perito Moreno.
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Parks · Nature · Wildlife
Find places to stay Apr 9 — 12:

Perito Moreno, Argentina — 1 night

Perito Moreno is a town in the northwest of Santa Cruz Province, Argentina, 25 km east of Lake Buenos Aires. On the 13th (Thu), get a dose of the wild on Zoyen Turismo and then get a new perspective on nature at Carlos Gradin Museo de Arqueologia.

For where to stay, photos, ratings, and other tourist information, read Perito Moreno holiday planning app.

Traveling by combination of flight and bus from Iguazu National Park to Perito Moreno takes 14.5 hours. Alternatively, you can drive; or take a bus. Prepare for colder weather when traveling from Iguazu National Park in April: high temperatures in Perito Moreno hover around 58°F and lows are around 39°F. Cap off your sightseeing on the 13th (Thu) early enough to travel back home.
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Wildlife · Outdoors · Tours · Museums
Find places to stay Apr 12 — 13:

Mexico travel guide

4.5
Ruins · Zipline · Beaches
Tailor-made for anyone seeking that traditional sun-and-sand experience, Mexico vacations allow visitors to explore nearly 10,000 km (6,200 mi) of picturesque coastlines. Idyllic beaches and favorable year-round weather aside, this diverse country with a rich pre-Colombian history allows tourists a chance to discover a fascinating cuisine, numerous archaeological sites, state-of-the-art museums, colonial-era haciendas, and outstanding examples of 21st-century architecture. Most visitors get to know the country by its cities, but if you want a well-rounded Mexico tour, spend some time exploring its jungles, cloud forests, Caribbean reefs, snowcapped volcanoes, vast deserts, and tranquil lagoons. Life is lived outdoors in Mexico, so wherever you go, don't forget to dine alfresco and stroll the country's colonial streets.
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Yucatan travel guide

4.5
Ruins · Geologic Formations · Architectural Buildings
A trip to Yucatan reveals a place that caters to the more tranquil of travelers interested in seeing Mexico away from big crowds and modern resorts. A good alternative for anyone disinclined to visit Cancun or Cabo San Lucas, this part of the country boasts numerous historical and natural attractions, including pristine mangrove forests, quaint colonial-era towns, and a string of unspoiled beaches on the Gulf of Mexico. Most visitors begin their tour of Yucatan in Merida, the under-the-radar state capital considered one of Mexico's safest and architecturally significant cities. From there, you're just a drive away from hundreds of Mayan ruins, proof that organized humans lived here as long ago as 800 BCE.
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Province of Misiones travel guide

3.9
Waterfalls · Gift & Specialty Shops · Landmarks