50 days in Panama City, San Jose & Mexico City Itinerary

50 days in Panama City, San Jose & Mexico City Itinerary

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50 days in Panama City, San Jose & Mexico City Itinerary

Start: Panama City, Panama
1
Panama City, Panama
— 9 nights
2
San Jose, Costa Rica
— 9 nights
Fly:  6​h 30​min
3
Mexico City, Mexico
— 31 nights
Fly:  7​h 30​min
End: San Francisco, United States

9
nights
Panama City, Panama

Panama City ©
Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Discover out-of-the-way places like Taboga Island Beaches and Iglesia del Carmen. Explore the numerous day-trip ideas around Panama City: Colon (Fort San Lorenzo, Isla Grande, & more) and Nature & Wildlife Tours (in Gamboa). There's still lots to do: make a trip to Panama Canal, see what you can catch with a fishing tour, identify plant and animal life at Punta Culebra Nature Center, and skim along the rocks with a canyoning and rapelling tour.

For photos, maps, traveler tips, and tourist information, you can read our Panama City online trip itinerary builder .

If you are flying in from Argentina, the closest major airports are Marcos A. Gelabert International Airport, Panama Pacific International Airport and Tocumen International Airport. December in Panama City sees daily highs of 36°C and lows of 28°C at night. Wrap up your sightseeing on the 12th (Wed) to allow time to travel to San Jose.

Things to do in Panama City

Historic Sites Parks Nature

Side Trips

Colon, Nature & Wildlife Tours, Taboga Island Beaches
Find places to stay Dec 3 — 12:
Highlights from your plan
Panama Canal ©
Panama Canal
Cinta Costera ©
Cinta Costera
Fishing Charters & Tours

9
nights
San Jose, Costa Rica

A trip to San Jose, the capital, commercial center, and cultural hub of Costa Rica, gives you a chance to experience the lively atmosphere and rich cultural past of this vibrant country.
Discover out-of-the-way places like Jade Museum and Catarata Del Toro Adventures. Get out of town with these interesting San Jose side-trips: Sarchi (Fabrica de Carretas Eloy Alfaro & Else Kientzler Botanical Garden), La Paz Waterfall Gardens (in Vara Blanca) and Poas Volcano (in Poas Volcano National Park). The adventure continues: stroll through Parque La Sabana, take in the architecture and design of Universidad de Costa Rica, look for gifts at Chocolatería Sibú, and explore the wealth of natural beauty at Tapanti National Park.

To see where to stay, ratings, and more tourist information, read our San Jose trip planner.

Getting from Panama City to San Jose by flight takes about 4.5 hours. Other options: drive; or take a bus. The time zone difference when traveling from Panama City to San Jose is minus 1 hour. Traveling from Panama City in December, expect San Jose to be a bit cooler, temps between 30°C and 22°C. Finish your sightseeing early on the 21st (Fri) so you can travel to Mexico City.

Things to do in San Jose

Parks Nature Outdoors

Side Trips

Sarchi, Cartago, Alajuela, Orosi, San Isidro
Find places to stay Dec 12 — 21:
Highlights from your plan
River Rafting & Tubing
Pre-Columbian Gold Museum ©
Pre-Columbian Gold Museum
Museo Nacional De Costa Rica ©
Museo Nacional De Costa Rica

31
nights
Mexico City, Mexico

Mexico City ©
Breathtakingly large, Mexico City provides a home for almost 9 million people living in nearly 1,700 distinct neighborhoods.
You'll explore the less-touristy side of things at Murales de Diego Rivera en la Secretaria de Educacion Publica and Chapultepec Park. Venture out of the city with trips to Jardines de Mexico (in Jojutla), Issstehuixtla (in Tehuixtla) and Cuernavaca (Palacio de Cortes, Canyoning & Rappelling Tours, & more). Spend the 14th (Mon) exploring nature at Cumbres Del Ajusco National Park. Spend the 13th (Sun) exploring nature at Parque Nacional Izta-Popo. The adventure continues: examine the collection at National Museum of Anthropology (Museo Nacional de Antropologia), get to know the fascinating history of Zocalo, admire the masterpieces at Palacio de Bellas Artes, and delve into the distant past at Museo del Templo Mayor.

To see other places to visit, ratings, maps, and other tourist information, read our Mexico City online trip builder .

Traveling by flight from San Jose to Mexico City takes 6.5 hours. Alternatively, you can drive; or take a bus. In December, Mexico City is slightly colder than San Jose - with highs of 26°C and lows of 9°C. Finish your sightseeing early on the 21st (Mon) to allow enough time to travel back home.

Things to do in Mexico City

Parks Historic Sites Museums

Side Trips

Cuernavaca, Pachuca, Tenancingo, Toluca, Atlixco
Find places to stay Dec 21 — Jan 21:
Highlights from your plan
Museo Nacional de Antropologia ©
Museo Nacional de Antropologia
Food Tours
Historic Center (Centro Historico) ©

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