27 days in Mexico & South America Itinerary

27 days in Mexico & South America Itinerary

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Route & dates

27 days in Mexico & South America Itinerary

Start: Rome, Italy
+2
Fly + foot + bus:  14​h 45​min
1
Playa del Carmen, Mexico
— 3 nights
Fly:  5​h 15​min
2
Mexico City, Mexico
— 4 nights
Fly:  7​h
3
Lima, Peru
— 2 nights
Fly + Drive:  12​h
4
Machu Picchu, Peru
— 1 night
+2
train + foot + bus:  3​h 15​min
5
Cusco, Peru
— 3 nights
Fly + bus:  1​h 45​min
6
La Paz, Bolivia
— 3 nights
Fly + taxi:  3​h 45​min
7
Uyuni, Bolivia
— 1 night
Drive + Fly:  12​h 30​min
8
Mendoza, Argentina
— 2 nights
9
Buenos Aires, Argentina
— 4 nights
Fly:  16​h 30​min
End: Rome, Italy

3
nights
Playa del Carmen, Mexico

Playa del Carmen ©
The tourist hub of the popular Mayan Riviera, upscale Playa del Carmen remains the jewel of Mexico's Caribbean coastline.
Explore Playa del Carmen's surroundings by going to Cobá Zona Arqueológica Cobá (in Coba), Scuba & Snorkeling (in Cozumel) and Tulum (Tulum Archaeological Site, Kaahal Home Tulum, & more). Next up on the itinerary: cool off at Xcaret Park and make a trip to Quinta Avenida.

To find other places to visit, more things to do, maps, and more tourist information, you can read our Playa del Carmen itinerary builder .

Rome, Italy to Playa del Carmen is an approximately 15-hour flight. You can also do a combination of train and flight. Due to the time zone difference, you'll gain 6 hours traveling from Rome to Playa del Carmen. In July, daytime highs in Playa del Carmen are 35°C, while nighttime lows are 26°C. Finish up your sightseeing early on the 9th (Thu) so you can travel to Mexico City.

Things to do in Playa del Carmen

Theme Parks Historic Sites Outdoors

Side Trips

Tulum, Cobá Zona Arqueológica Cobá, Scuba & Snorkeling
Find places to stay Jul 6 — 9:
Highlights from your plan
Tulum Archaeological Site ©
Tulum Archaeological Site
Xcaret Park ©
Xcaret Park
Scuba & Snorkeling

4
nights
Mexico City, Mexico

Mexico City ©
Breathtakingly large, Mexico City provides a home for almost 9 million people living in nearly 1,700 distinct neighborhoods.
Step out of Mexico City with an excursion to Zona Arqueológica de Teotihuacan Estacionamiento Puerta 5 in San Juan Teotihuacan--about 1h 15 min away. The adventure continues: examine the collection at Museo Nacional de Antropologia, explore the historical opulence of Chapultepec Castle, appreciate the extensive heritage of Zocalo, and admire the masterpieces at Palacio de Bellas Artes.

For more things to do, reviews, and more tourist information, use the Mexico City trip maker site .

Traveling by flight from Playa del Carmen to Mexico City takes 5.5 hours. Alternatively, you can do a combination of flight and bus; or drive. The time zone changes from Eastern Standard Time to Central Standard Time, which is usually a -1 hour difference. Traveling from Playa del Carmen in July, things will get slightly colder in Mexico City: highs are around 27°C and lows about 15°C. Finish your sightseeing early on the 13th (Mon) to allow enough time to travel to Lima.

Things to do in Mexico City

Historic Sites Museums Nature

Side Trip

Zona Arqueológica de Teotihuacan Estacionamiento Puerta 5
Find places to stay Jul 9 — 13:
Highlights from your plan
Museo Nacional de Antropologia ©
Museo Nacional de Antropologia
Palacio de Bellas Artes ©
Palacio de Bellas Artes

2
nights
Lima, Peru

Lima ©
Founded in 1535 by Spanish explorer Francisco Pizarro, Lima represents an interesting blend of modern attractions and preserved colonial architecture, much of it clustered in the World Heritage-listed city center.
Start off your visit on the 14th (Tue): take an in-depth tour of Museo Larco, don't miss a visit to Plaza de Armas (Plaza Mayor), pause for some serene contemplation at Iglesia y Convento de San Francisco, then take in the spiritual surroundings of San Pedro Church (Iglesia de San Pedro), and finally stroll around Circuito Magico Del Agua. On the next day, take a stroll through Miraflores, delve into the distant past at Huaca Pucllana, and then look for gifts at Dedalo arte & artesania.

For more things to do, traveler tips, photos, and tourist information, you can read our Lima sightseeing app .

Getting from Mexico City to Lima by flight takes about 7 hours. The time zone changes from Central Standard Time to Peru Time, which is usually a 1 hour difference. When traveling from Mexico City in July, plan for slightly colder days and about the same nights in Lima: temperatures range from 22°C by day to 19°C at night. Wrap up your sightseeing on the 15th (Wed) early enough to travel to Machu Picchu.

Things to do in Lima

Historic Sites Shopping Museums
Find places to stay Jul 13 — 15:
Highlights from your plan
Huaca Pucllana ©
Huaca Pucllana
Museo Larco ©
Museo Larco
Plaza de Armas (Plaza Mayor) ©
Plaza de Armas (Plaza Mayor)

1
night
Machu Picchu, Peru

Machu Picchu ©
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Kick off your visit on the 16th (Thu): take in nature's colorful creations at Los Jardines de Mandor and then delve into the distant past at Winay Wayna. Get ready for a full day of sightseeing on the 17th (Fri): explore the ancient world of Santuario Historico de Machu Picchu and then make a trip to Intipuncu.

To see photos, maps, other places to visit, and tourist information, you can read our Machu Picchu driving holiday site .

You can do a combination of flight and car from Lima to Machu Picchu in 12 hours. Other options are to drive; or do a combination of bus and taxi. Finish your sightseeing early on the 17th (Fri) so you can travel to Cusco.

Things to do in Machu Picchu

Historic Sites Parks Wildlife
Find places to stay Jul 16 — 17:
Highlights from your plan
Santuario Historico de Machu Picchu ©
Winay Wayna ©
Winay Wayna
Intipuncu ©
Intipuncu

3
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
You'll find plenty of places to visit near Cusco: Maras (Salinas de Maras & Moray). There's much more to do: delve into the distant past at Sacsayhuaman, contemplate the long history of Plaza de Armas, trek along exploor, and explore the world behind art at Museo de Arte Precolombino.

Plan a Cusco trip in moments using our itinerary builder.

Do a combination of train and bus from Machu Picchu to Cusco in 3.5 hours. Alternatively, you can take a train; or drive. In July in Cusco, expect temperatures between 24°C during the day and 1°C at night. Cap off your sightseeing on the 20th (Mon) early enough to travel to La Paz.

Things to do in Cusco

Historic Sites Parks Nature

Side Trips

Maras, Sacred Valley of the Incas
Find places to stay Jul 17 — 20:
Highlights from your plan
exploor ©
exploor
Sacsayhuaman ©
Sacsayhuaman
Sacred Valley of the Incas ©
Sacred Valley of the Incas

3
nights
La Paz, Bolivia

La Paz ©
Take a moment to catch your breath as you commence your holiday in La Paz.
Spend the 22nd (Wed) exploring the striking scenery along WMDR Yungas Road. There's much more to do: steep yourself in history at Tiwanaku, push the limits with an extreme tour, have fun at Urban Rush Bolivia, and don't miss a visit to Mercado de Las Brujas.

For reviews, photos, traveler tips, and more tourist information, go to the La Paz online road trip planner .

Do a combination of flight and bus from Cusco to La Paz in 2 hours. Alternatively, you can drive; or take a bus. The time zone difference moving from Peru Time (PET) to Bolivia Time (BOT) is 1 hour. Traveling from Cusco in July, expect La Paz to be a bit cooler, temps between 17°C and -4°C. Wrap up your sightseeing on the 23rd (Thu) early enough to travel to Uyuni.

Things to do in La Paz

Outdoors Scenic Drive Tours
Find places to stay Jul 20 — 23:
Highlights from your plan
Urban Rush Bolivia ©
Urban Rush Bolivia
Tiwanaku ©
Tiwanaku
WMDR Yungas Road ©
WMDR Yungas Road

1
night
Uyuni, Bolivia

Uyuni ©
Emptiness surrounds the desert outpost of Uyuni, the gateway to the world's largest salt flats.
Start off your visit on the 24th (Fri): step off the mainland to explore Isla Incahuasi and then take in the dramatic natural features at Salar de Uyuni.

For maps, more things to do, and other tourist information, go to the Uyuni vacation planner.

Traveling by combination of flight and taxi from La Paz to Uyuni takes 4 hours. Alternatively, you can drive; or do a combination of bus and taxi. When traveling from La Paz in July, plan for slightly colder days and a bit warmer nights in Uyuni: temperatures range from 4°C by day to 3°C at night. Finish up your sightseeing early on the 24th (Fri) so you can travel to Mendoza.

Things to do in Uyuni

Nature Parks
Find places to stay Jul 23 — 24:
Highlights from your plan
Salar de Uyuni ©
Salar de Uyuni
Isla Incahuasi ©
Isla Incahuasi

2
nights
Mendoza, Argentina

Famed for its neat vineyards and thriving wine production, Mendoza remains the place to visit for a pleasant combination of relaxation and recreation.
Take a break from Mendoza with a short trip to Valle de Uco in Tupungato, about 1h 25 min away. The adventure continues: walk around Parque General San Martin, learn about winemaking at Bodega La Azul, and let your taste buds guide you at a local gastronomic tour.

For more things to do, reviews, maps, and other tourist information, refer to the Mendoza visit planner.

Traveling by combination of car and flight from Uyuni to Mendoza takes 12.5 hours. Alternatively, you can do a combination of car, flight, and bus; or drive. The time zone changes from Bolivia Time (BOT) to Argentine Time (ART), which is usually a 1 hour difference. Traveling from Uyuni in July, expect nights in Mendoza to be about the same, around 2°C, while days are somewhat warmer, around 17°C. Wrap up your sightseeing on the 27th (Mon) early enough to travel to Buenos Aires.

Things to do in Mendoza

Wineries Tours Parks

Side Trip

Valle de Uco
Find places to stay Jul 25 — 27:
Highlights from your plan
Food Tours
Parque General San Martin ©
Parque General San Martin
Bodega Roberto Bonfanti ©
Bodega Roberto Bonfanti

4
nights
Buenos Aires, Argentina

Buenos Aires ©
Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Buenos Aires is known for nightlife, museums, parks, historic sites, and shopping. Your plan includes some of its best attractions: make a trip to Cemiterio de Recoleta, admire the striking features of El Ateneo Grand Splendid, steep yourself in history at Casa Rosada, and admire the masterpieces at Museo Nacional de Bellas Artes.

For more things to do, traveler tips, other places to visit, and other tourist information, you can read our Buenos Aires driving holiday planner .

Traveling by flight from Mendoza to Buenos Aires takes 3.5 hours. Alternatively, you can drive; or take a bus. Traveling from Mendoza in July, plan for a bit warmer nights in Buenos Aires, with lows around 10°C. Finish up your sightseeing early on the 31st (Fri) so you can travel back home.

Things to do in Buenos Aires

Neighborhoods Shopping Historic Sites
Find places to stay Jul 27 — 31:
Highlights from your plan
Puerto Madero ©
Puerto Madero
Cemiterio de Recoleta ©
Cemiterio de Recoleta
Parque 3 de Febrero ©
Parque 3 de Febrero

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